A promising approach for asthma treatment by multiwayly modulating toll-like receptors.

Asthma is a major epidemic affecting up to one third people in developed countries over the last decades, and making a crucial impact on morbidity rates. The classical characters of asthma in human are airway inflammation, airway hyperreactivity, and airway remodeling. Hygiene hypothesis, inflammation cells and signaling pathway in asthma were involved in Toll-like receptors (TLRs). TLRs are a kind of pattern recognition receptors, which are important in recognition of various pathogens. TLRs have been seen as a key target for asthma treatment, so a promising approach for asthma treatment was adopted to the multiwayly modulating toll-like receptors way.